GHK-Cu calculator
This is a research reference, not a product for sale or a dosing recommendation. No amount is selected for GHK-Cu. A listed name does not mean it is supplied in a vial or should be injected.
About GHK-Cu
GHK-Cu is the copper(II) complex of glycyl-L-histidyl-L-lysine, a naturally occurring tripeptide found in human plasma. Research has focused on its interaction with fibroblasts and extracellular-matrix remodeling, including collagen synthesis observed in cell culture. Broader claims about regeneration draw partly on cellular and gene-expression studies, which cannot establish clinical outcomes. Evidence depends on the formulation and context, and GHK-Cu is not an FDA-approved medicine for a defined indication.
At a glance
- Class
- Copper(II)-binding tripeptide complex; GHK is glycyl-L-histidyl-L-lysine.
- Studied mechanism
- Cell studies report effects on fibroblast collagen production and extracellular-matrix remodeling.
- Evidence context
- Key mechanistic findings come from cell culture; they do not demonstrate that the complex produces clinical tissue-repair outcomes.
Blank arithmetic calculator
For independently verified inputs, concentration equals entered vial amount in mg divided by added liquid in mL. Entered requested mg divided by concentration gives mL; multiplying mL by the actual syringe markings per mL gives units. Enable JavaScript to use the calculator. This math does not establish that a compound is suitable for injection.
Common questions
What does the Cu in GHK-Cu refer to?
It denotes copper(II) bound to the tripeptide GHK. The complex is distinct from the unbound GHK peptide.
What is the evidence for GHK-Cu and collagen?
A fibroblast-culture study reported increased collagen synthesis with the GHK-Cu complex. A cell-culture result is mechanistic evidence, not proof of a clinical effect.
Research & references
- Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+
- GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
- In vitro observations on the influence of copper peptide aids for the LED photoirradiation of fibroblast collagen synthesis
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