Semax calculator
This is a research reference, not a product for sale or a dosing recommendation. No amount is selected for Semax. A listed name does not mean it is supplied in a vial or should be injected.
About Semax
Semax is a synthetic heptapeptide modeled on ACTH(4–10), with a modified sequence that incorporates Pro-Gly-Pro. Its research profile centers on neurotrophin signaling: experiments have reported changes in BDNF and its receptor TrkB, mainly in animal or cell models. Clinical reports, including studies concerning ischemic stroke, are concentrated in Russian-language literature and vary in reporting quality. Those findings do not establish broad clinical efficacy; Semax is not FDA-approved.
At a glance
- Class
- Synthetic ACTH(4–10)-related heptapeptide, studied for neurotrophic and cognitive effects.
- Studied mechanism
- Preclinical work reports changes in BDNF and TrkB expression; the pathway's relevance to people is uncertain.
- Evidence context
- Includes rat studies and Russian clinical reports on ischemic stroke; the clinical literature is not equivalent to a large, independently replicated international evidence base.
Blank arithmetic calculator
For independently verified inputs, concentration equals entered vial amount in mg divided by added liquid in mL. Entered requested mg divided by concentration gives mL; multiplying mL by the actual syringe markings per mL gives units. Enable JavaScript to use the calculator. This math does not establish that a compound is suitable for injection.
Common questions
What is Semax modeled on?
It is a seven-residue synthetic analog of ACTH(4–10) that incorporates Pro-Gly-Pro in its sequence. It is not full-length ACTH.
What do studies report about Semax and BDNF?
Cell and rat studies report changes in BDNF and TrkB expression. These preclinical findings do not by themselves show a clinical benefit in people.
Research & references
- Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
- The efficacy of Semax in the treatment of patients at different stages of ischemic stroke
- The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
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